Synthesis and evaluation of novel chromone analogs for their inhibitory activity against interleukin-5

P Thanigaimalai, TA Le Hoang, KC Lee…

Index: Thanigaimalai, Pillaiyar; Le Hoang, Tuan Anh; Lee, Ki-Cheul; Sharma, Vinay K.; Bang, Seong-Cheol; Yun, Jun Ho; Roh, Eunmiri; Kim, Youngsoo; Jung, Sang-Hun European Journal of Medicinal Chemistry, 2010 , vol. 45, # 6 p. 2531 - 2536

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Citation Number: 19

Abstract

A novel series of chromone analogs were synthesized and evaluated for their inhibitory activity against interleukin-5. Among them compounds 5-Cyclohexylmethoxy-3-(4- hydroxybenzyl)-4H-chromen-4-one (6a, 98% inhibition at 30 μM, IC50< 3.0 μM) and 5- Cyclohyxylmethoxy-3-(hydroxymethyl)-4H-chromen-4-one (8a, 84% inhibition at 30 μM, IC50= 7.6 μM) showed most potent activity. The structural requirement of chromone ...