Synergistic effect of additives on cyclopropanation of olefins
D Cheng, D Huang, Y Shi
Index: Cheng, Donghao; Huang, Deshun; Shi, Yian Organic and Biomolecular Chemistry, 2013 , vol. 11, # 34 p. 5588 - 5591
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Citation Number: 4
Abstract
Cyclopropanes are present in many biological and medicinal molecules, 1 and are synthetically useful intermediates. 2 The Simmons–Smith reaction is a very effective method to synthesize cyclopropanes from olefins (Scheme 1). 3 Since the initial report of the Simmons–Smith reaction, 4 lots of modifications have been reported. 5 A variety of strategies have also been developed to generate various zinc species, including XZnCH 2 X, 6a,b RZnCH 2 I or ...
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