Synlett

A new preparative route to substituted dibenzofurans by benzannulation reaction. An application to the synthesis of cannabifuran

S Serra, C Fuganti

Index: Serra, Stefano; Fuganti, Claudio Synlett, 2003 , # 13 p. 2005 - 2008

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Citation Number: 4

Abstract

Abstract A new regioselective pathway to substituted dibenzofuran derivatives is described here. According to this procedure substituted 1-acetoxy-3-alkoxycarbonyl dibenzofurans are obtained by treatment of 6-(2-methoxyaryl)-3-alkoxycarbonylhex-3-en-5-ynoic acids with acetic anhydride in the presence of sodium acetate. The latter acids are prepared from the easily available substituted o-iodo-anisoles by Sonogashira coupling with propargylic ...