Total synthesis and absolute stereochemistry of polygalolides A and B

S Nakamura, Y Sugano, F Kikuchi…

Index: Nakamura, Seiichi; Sugano, Yukihito; Kikuchi, Fumiaki; Hashimoto, Shunichi Angewandte Chemie - International Edition, 2006 , vol. 45, # 39 p. 6532 - 6535

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Citation Number: 59

Abstract

In 2003, Wei and co-workers reported the isolation and structural elucidation of the polygalolides A (1) and B (2) obtained from Polygala fallax Hemsl., a medicinal plant from which extracts are used as tonics and antihepatitis drugs in China.[1] The structure and relative configuration of the polygalolides were determined on the basis of NMR spectroscopic data. However, the issue of the absolute stereochemistry of the molecules ...