cis-1, 3, 4, 6, 7, 11b-Hexahydro-2-methyl-7-phenyl-2H-pyrazino [2, 1-a] isoquinoline: a new atypical antidepressant

RC Griffith, RJ Gentile, RC Robichaud…

Index: Griffith; Gentile; Robichaud; Frankenheim Journal of medicinal chemistry, 1984 , vol. 27, # 8 p. 995 - 1003

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Citation Number: 11

Abstract

Molecular modelling studies suggested the synthesis of cis-1, 3, 4, 6, 7, 11b-hexahydro-2- methyl-7-phenyl-2H-pyrazino [2, 1-a] isoquinoline (7a) as a rigid analogue of the atypical antidepressant mianserin. Acylation of 2, 2-diphenylethylamine with chloroacetyl chloride gives the chloroacetamide (2). Cyclization of 2 with Pz06 in xylene provides l-(chloromethyl)- 3, 4-dihydro-4-phenylisoquinoline (3). Amination of 3, followed by reduction, gives the ...

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