Rhodium??Catalyzed Cascade Reaction: Aryl Addition/Intramolecular Esterification to Access 3??Aryl and 3??Alkenyl Phthalides

…, G Lv, W Wang, M Zhang, J Cheng

Index: Ye, Zhishi; Lv, Guanglei; Wang, Wenhui; Zhang, Manli; Cheng, Jiang Angewandte Chemie - International Edition, 2010 , vol. 49, # 21 p. 3671 - 3674

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Citation Number: 28

Abstract

Phthalides (isobenzofuranone), a family of five-membered lactones in plants, are important building blocks in a large number of biologically active compounds.[1] 3-Arylphthalides, for example, are useful intermediates for the synthesis of triand tetracyclic natural products such as anthracycline antibiotics.[2] Approaches have been developed for the synthesis of these organic skeletons.[3] The tandem carbonylation of benzylic alcohol and ortho-halo ...