Synthesis and pharmacological activity of quaternary ammonium salts of certain bisindoles and pyrroloindoles of different structures

SA Samsoniya, BA Medvedev, SV Dolidze…

Index: Samsoniya, Sh. A.; Medvedev, B. A.; Dolidze, S. V.; Cheshmaritashvili, M. G.; Nguen Hue Din; et al. Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 1 p. 14 - 17 Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 1 p. 29 - 31

Full Text: HTML

Citation Number: 0

Abstract

We have already reported [i] the synthesis and curarelike properties of bisgramine based on bis (5-indolyl) methane with dimethylaminomethyl groups at the 3-position of the indole ring. To obtain isogramine V based on bis (5-indolyl) methane with dimethylaminoethyl groups at the 2-position, we carried out an aminolysis of a diacid chloride of 2, 2'-dihydrocarbonyl-bis (5-indolyl) methane [7] by an aqueous solution of dimethylamine, followed by lithium ...