Biomacromolecules

Cationic spacer arm design strategy for control of antimicrobial activity and conformation of amphiphilic methacrylate random copolymers

EF Palermo, S Vemparala, K Kuroda

Index: Palermo, Edmund F.; Vemparala, Satyavani; Kuroda, Kenichi Biomacromolecules, 2012 , vol. 13, # 5 p. 1632 - 1641

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Citation Number: 39

Abstract

Antimicrobial and hemolytic activities of amphiphilic random copolymers were modulated by the structure of the cationic side chain spacer arms, including 2-aminoethylene, 4- aminobutylene, and 6-aminohexylene groups. Cationic amphiphilic random copolymers with ethyl methacrylate (EMA) comonomer were prepared with a range of comonomer fractions, and the library of copolymers was screened for antimicrobial and hemolytic activities. ...