Traceless Fischer indole synthesis on the solid phase

C Rosenbaum, C Katzka, A Marzinzik…

Index: Rosenbaum, Claudia; Katzka, Catherine; Marzinzik, Andreas; Waldmann, Herbert Chemical Communications, 2003 , # 15 p. 1822 - 1823

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Citation Number: 9

Abstract

The Fischer indole synthesis using polymer-bound hydrazines is employed as the key step for the development of a traceless indole synthesis on a solid support. ... We now report on the development of a traceless 5 solid phase indole synthesis employing the Fischer indole synthesis 6 as the key step. In planning the synthesis we envisioned generating hydrazines 2 on a solid support and treating them with appropriate ketones under typical conditions of the Fischer indole ...