Synthesis and in vitro antibacterial activity of 7-(4-alkoxyimino-3-amino-3-methylpiperidin-1-yl) fluoroquinolone derivatives

Y Chai, ZL Wan, B Wang, HY Guo, ML Liu

Index: Chai, Yun; Wan, Zhi-Long; Wang, Bo; Guo, Hui-Yuan; Liu, Ming-Liang European Journal of Medicinal Chemistry, 2009 , vol. 44, # 10 p. 4063 - 4069

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Citation Number: 39

Abstract

A series of novel 7-(4-alkoxyimino-3-amino-3-methylpiperidin-1-yl) fluoroquinolone derivatives were designed, synthesized and characterized by 1H NMR, MS and HRMS. These fluoroquinolones were evaluated for in vitro antibacterial activity against representative Gram-positive and Gram-negative strains. All of the title compounds have considerable activity against the twelve strains, and exhibit exceptional potency in ...