Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission …

JI Andrés, J Alcázar, JM Cid, M De Angelis…

Index: Andres, Jose-Ignacio; Alcazar, Jesus; Cid, Jose Maria; De Angelis, Meri; Iturrino, Laura; Trabanco, Andres A.; Langlois, Xavier; Lavreysen, Hilde; Celen, Sofie; Bormans, Guy Journal of Medicinal Chemistry, 2012 , vol. 55, # 20 p. 8685 - 8699,15 Title/Abstract Full Text Show Details Andres, Jose-Ignacio; Alcazar, Jesus; Cid, Jose Maria; De Angelis, Meri; Iturrino, Laura; Langlois, Xavier; Lavreysen, Hilde; Trabanco, Andres A.; Celen, Sofie; Bormans, Guy Journal of Medicinal Chemistry, 2012 , vol. 55, # 20 p. 8685 - 8699

Full Text: HTML

Citation Number: 16

Abstract

The synthesis and in vitro and in vivo evaluation of a new series of 7-(phenylpiperidinyl)-1, 2, 4-triazolo [4, 3-a] pyridines, which were conveniently radiolabeled with carbon-11, as potential positron emission tomography (PET) radiotracers for in vivo imaging of the allosteric binding site of the metabotropic glutamate (mGlu) receptor subtype 2 are described. The synthesized compounds proved to be potent and selective positive ...