General Zinc??Catalyzed Conia??Ene Reactions of 1, 3??Dicarbonyl Compounds with Alkynes Including the Classically Challenging Substrates under Neat Conditions

CL Deng, RJ Song, YL Liu, JH Li

Index: Deng, Chen-Liang; Song, Ren-Jie; Liu, Yi-Lin; Li, Jin-Heng Advanced Synthesis and Catalysis, 2009 , vol. 351, # 18 p. 3096 - 3100

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Citation Number: 25

Abstract

Abstract A simple, versatile new approach to four-membered ring to six-membered ring products has been developed by zinc-catalyzed intramolecular Conia-ene reactions of 1, 3- dicarbonyl compounds with alkynes. This new route allows a wide range of dicarbonyl compounds, including the classically challenging 1, 3-diesters and N, N′-disubstituted 1, 3- keto amides, to be used for the Conia-ene reaction with inexpensive zinc chloride (ZnCl 2) ...