Synthesis and antiprotozoal activity of 4-arylcoumarins

JT Pierson, A Dumètre, S Hutter, F Delmas…

Index: Pierson, Jean-Thomas; Dumetre, Aurelien; Hutter, Sebastien; Delmas, Florence; Laget, Michele; Finet, Jean-Pierre; Azas, Nadine; Combes, Sebastien European Journal of Medicinal Chemistry, 2010 , vol. 45, # 3 p. 864 - 869

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Citation Number: 39

Abstract

A large series of 4-arylcoumarins was synthesized by Suzuki-Miyaura cross-coupling reaction and evaluated for antiprotozoal activity against Plasmodium falciparum and Leishmania donovani. Several compounds were found to strongly inhibit the proliferation of human cell line and/or parasites. The 4-(3, 4-dimethoxyphenyl)-6, 7-dimethoxycoumarin exhibit a potent activity on L. donovani amastigotes with a selectivity index (SI= 265) twice ...