Synthesis

Synthesis of thiophene analogues of the tacrine series

D Thomae, G Kirsch, P Seck

Index: Thomae, David; Kirsch, Gilbert; Seck, Pierre Synthesis, 2007 , # 7 p. 1027 - 1032

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Citation Number: 29

Abstract

Alzheimer's disease is a form of dementia of older people that looks set to be a major problem in the coming decade. [1] One possible treatment is to inhibit acetylcholinesterase, which plays a role in the formation of the β-amyloid plaque. The first acetylcholinesterase inhibitor used in this context was tacrine (I), sold under the name COGNEX ® (Figure [1] ). The hydroxy derivative of tacrine is velnacrine (II). In order to investigate the biological effects of structural ...