Phosphorus, Sulfur, and Silicon

Selenium analogues of anti-thyroid drugs

G Roy, G Mugesh

Index: Roy, Gouriprasanna; Mugesh, Govindasamy Phosphorus, Sulfur and Silicon and the Related Elements, 2008 , vol. 183, # 4 p. 908 - 923

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Citation Number: 5

Abstract

The inhibition of lactoperoxidase (LPO)-catalyzed oxidation of ABTS by anti-thyroid drugs and related derivatives is described. The commonly used anti-thyroid agent methimazole (MMI) inhibits the LPO with an IC 50 value of 7.0±1.1 μ M which is much lower than that of