Organic letters

Facile regiocontrolled synthesis of trialkyl-substituted pyrazines

TA Elmaaty, LW Castle

Index: Elmaaty, Tarek Abou; Castle, Lyle W. Organic Letters, 2005 , vol. 7, # 24 p. 5529 - 5530

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Citation Number: 15

Abstract

α-Nitro ketones can be transformed selectively into trialkyl-substituted pyrazines via reaction with α-amino ketones using octyl viologen as an electron-transfer reagent. The new synthetic method, and the optimal reaction conditions that allow for the regiochemical control, are described.