Synthesis and evaluation of β-carboline derivatives as potential monoamine oxidase inhibitors

…, R Frederick, B Masereel, S Vincent, J Wouters

Index: Reniers; Robert; Frederick; Masereel; Vincent; Wouters Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 1 p. 134 - 144

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Citation Number: 45

Abstract

Previous studies have shown that harmine is a reversible inhibitor of human monoamine oxidase A (MAO-A). Moreover, the crystal structure of human MAO-A in complex with harmine has been recently solved. This crystal structure shows that close to the methoxy group of the harmine moiety, a lipophilic pocket is left vacant within the binding site of human MAO-A. Our objective was to optimize the β-carboline series against human MAO- ...