Pharmaceutical research

Topical delivery of a model phenolic drug: alkyloxycarbonyl prodrugs of acetaminophen

SC Wasdo, KB Sloan

Index: Wasdo, Scott C.; Sloan, Kenneth B. Pharmaceutical Research, 2004 , vol. 21, # 6 p. 940 - 946

Full Text: HTML

Citation Number: 26

Abstract

Abstract Purpose. To determine whether the delivery of a phenolic parent drug by its alkyloxycarbonyl (AOC) prodrugs through hairless mouse skin would show similar dependencies on water and lipid solubilities that similar prodrugs of more polar heterocyclic amide and imide parent drugs have shown. Methods. Flux through hairless mouse skin from suspensions in isopropyl myristate (J MIPM), solubilities in IPM (S IPM) and water (S AQ), ...