Design, synthesis and evaluation of 5-substituted amino-2, 4-diamino-8-chloropyrimido-[4, 5-b] quinolines as novel antimalarials

AA Joshi, SS Narkhede, CL Viswanathan

Index: Joshi, Advait A.; Narkhede, Sachin S.; Viswanathan Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 73 - 76

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Citation Number: 58

Abstract

Novel 5-substituted amino-2, 4-diamino-8-chloropyrimido-[4, 5-b] quinolines were designed based on a pharmacophore developed for potent antimalarial activity using Chem-X and MOE softwares. The designed molecules were synthesized by following a novel route and were evaluated by Rane's test for blood schizonticidal activity in mice infected by Plasmodium berghei. Based on the Mean Survival Time (MST) data, of the nine ...