Zinc-mediated acylation and sulfonation of pyrrole and its derivatives

JS Yadav, BVS Reddy, G Kondaji, RS Rao, SP Kumar

Index: Yadav; Reddy; Kondaji; Srinivasa Rao; Praveen Kumar Tetrahedron Letters, 2002 , vol. 43, # 45 p. 8133 - 8135

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Citation Number: 32

Abstract

The 2-ketopyrrole moiety, although rarely reported, is apparently biologically important as evidenced by its presence in naturally occurring molecules such as X-14547A, 1., and and A-23187 (calcimycin). 2 Generally, 2-acetyl pyrroles are prepared by the Vilsmeier–Haack method using POCl 3 and N,N-dimethylacetamide. 3., , , and Other methods for the acylation of pyrroles involve the isomerization of N-acetyl pyrroles by thermal rearrangement at high temperature, ...