Tetrahedron Letters

CC-connective synthesis of α-dialkylamino-ketones from aldehydes and sec.-amines

D Enders, H Lotter

Index: Enders, Dieter; Lotter, Hermann Tetrahedron Letters, 1982 , vol. 23, # 6 p. 639 - 642

Full Text: HTML

Citation Number: 21

Abstract

Abstract A simple and efficient 3-step synthesis of α-dialkylamino-ketones 3 starting from aldehydes and sec.-amines is described. The unsymmetrically aminoketones are obtained as pure regioisomers via reaction of metalated α-aminonitriles 1 with aldehydes, followed by thermal HCN-elimination/tautomerization.