Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: Novel agonists for the CB 1 receptor

…, MJ Stoermer, M Robinson, CE Wright, K McRae…

Index: Moloney, Gerard P.; Angus, James A.; Robertson, Alan D.; Stoermer, Martin J.; Robinson, Michael; Wright, Christine E.; McRae, Ken; Christopoulos, Arthur European Journal of Medicinal Chemistry, 2008 , vol. 43, # 3 p. 513 - 539

Full Text: HTML

Citation Number: 17

Abstract

An exploratory chemical effort has been undertaken to develop a novel series of compounds as selective CB1 agonists. It is hoped that compounds of this type will have clinical utility in pain control, and cerebral ischaemia following stroke or traumatic head injury. We report here medicinal chemistry studies directed towards the investigation of a series of 1- substituted-indole-3-oxadiazoles as potential CB1 agonists.