The Journal of Organic Chemistry

Kinetic studies and stereochemical considerations for the rearrangement of 1-(o-chlorophenyl)-2-bromo-2-chloro-1-propyl trifluoroacetate

BL Jensen, J Jewett-Bronson

Index: Jensen, Bruce L.; Jewett-Bronson, Joanne Journal of Organic Chemistry, 1982 , vol. 47, # 14 p. 2795 - 2798

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Abstract

three-step sequence. Monochlorination of 3 was carried out in methylene chloride with an equimolar amount of chlorine. The reaction was monitored via NMR and upon appearance of a singlet at 2.3 ppm the reaction was quenched. Traces of starting material and the dichloro ketone were removed by spinning-band distillation. Preparation of the bromo chloro ketone was accomplished by treating the monochloro ketone with N-bromosuccinimide in ...