2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents

…, M Falahati, E Lotfali, S Rajabalian, SA Ebrahimi…

Index: Emami, Saeed; Foroumadi, Alireza; Falahati, Mehraban; Lotfali, Ensieh; Rajabalian, Saeed; Ebrahimi, Soltan-Ahmed; Farahyar, Shirin; Shafiee, Abbas Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 141 - 146

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Citation Number: 73

Abstract

2-Hydroxyphenacyl azole and 2-hydroxyphenacyl azolium compounds have been described as a new class of azole antifungals. Most target compounds showed significant in vitro antifungal activities against tested fungi (Candida albicans, Saccharomyces cerevisiae, Aspergillus niger, and Microsporum gypseum) with low MICs values included in the range of 0.25–32μg/mL comparable to reference drug fluconazole. The most active compounds ...