Propenyl carboxamide derivatives as antagonists of platelet-activating factor

…, FA Mennona, JW Tilley, RW Kierstead…

Index: Guthrie, Robert W.; Kaplan, Gerald L.; Mennona, Francis A.; Tilley, Jefferson W.; Kierstead, Richard W.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2856 - 2864

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Citation Number: 23

Abstract

A series of N-[4-(3-pyridiny1) butyll 3-substituted propenyl carboxamide derivatives bearing an unsaturated bicyclic moiety in the 3-position was prepared and evaluated for PAF (platelet activating factor) antagonist activity. These compounds represent conformationally constrained direct analogues of the corresponding potent &arylpentadienecarboxamides (5). Most of the new compounds were active in a PAF-binding assay employing whole, ...