Facile reduction of malonate derivatives using NaBH 4/Br 2: an efficient route to 1, 3-diols

…, H Mashima, C Savarin, G Humphrey, I Davies

Index: Tudge, Matthew; Mashima, Hiroko; Savarin, Cecile; Humphrey, Guy; Davies, Ian Tetrahedron Letters, 2008 , vol. 49, # 6 p. 1041 - 1044

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Citation Number: 13

Abstract

Borane–dimethoxyethane generated from sodium borohydride–bromine mixtures efficiently reduces a wide range of malonate derivatives to the corresponding 1, 3-diols. This new reagent system represents a milder alternative to current methods available, providing the requisite 1, 3-diols in higher yields over shorter reaction times.

A formal total synthesis of (±)-strigol

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