A new, elegant route to a key intermediate for the synthesis of 9 (0)-methanoprostacyclin
A Barco, S Benetti, GP Pollini, PG Baraldi…
Index: Barco, Achille; Benetti, Simonetta; Pollini, Gian Piero Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4776 - 4778
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Citation Number: 45
Abstract
7 the involvement of the acetalization-selective deacetalization technique, with subsequent loss of overall yield, to differentiate the two carbonyl groups of 3. We describe here a novel synthesis of the retrosynthetically predictable trifunctionalized bicyclo [3.3. 0] octane 9, an advanced intermediate for the synthesis of 9 (0)-methanoprostacyclin, as outlined in Scheme I.
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