Total Synthesis and Olfactory Evaluation of 5β, 10??Dimethyl??des??A??18??nor??androstan??13β??ol: A Potential Human Pheromone?

P Kraft, K Popaj

Index: Kraft, Philip; Popaj, Kasim European Journal of Organic Chemistry, 2004 , # 24 p. 4995 - 5002

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Citation Number: 5

Abstract

Abstract 5β, 10-Dimethyl-des-A-18-nor-androstan-13β-ol (Limdrostanol, 11) was suspected to be the underlying parent steroid responsible for the interesting urinous-animalic, woody olfactory properties of the commercial odorant Timberol®(6− 9), and the captives Norlimbanol®(7) and Limbanol®(10), and so could constitute a potential human pheromone. We report the first synthesis of 11, starting with treatment of the bis-Grignard ...