Synlett

Palladium-catalyzed intramolecular CH arylation of five-membered N-heterocycles

N Arai, M Takahashi, M Mitani, A Mori

Index: Arai, Nobumichi; Takahashi, Masabumi; Mitani, Makoto; Mori, Atsunori Synlett, 2006 , # 18 p. 3170 - 3172

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Citation Number: 31

Abstract

Abstract Intramolecular CH arylation of imidazole derivatives is carried out in the presence of a palladium catalyst to form fused heteroaromatic compounds. The reaction of imidazole with 2-iodobenzyl bromide with NaH gives the cyclization precursor in an excellent yield. This then undergoes a palladium-catalyzed intramolecular CH arylation at 100 C to form 5H- imidazo [5, 1-a] isoindole in 78% yield.