4-Hydroxy-2-quinolones. 112. Reaction of 2-ethoxycarbonylmethyl-4H-3, 1-benzoxazin-4-one with active methylene compounds
…, LV Sidorenko, OV Gorokhova, SV Slobodzyan
Index: Ukrainets; Sidorenko; Gorokhova; Slobodzyan Chemistry of Heterocyclic Compounds, 2007 , vol. 43, # 1 p. 63 - 66
Full Text: HTML
Citation Number: 0
Abstract
Abstract The reaction of 2-ethoxycarbonylmethyl-4H-3, 1-benzoxazin-4-one with malononitrile in dry pyridine leads to 1-hydroxy-3, 6-dioxo-4, 6-dihydro-3H-pyrimido [1, 2-a] quinoline-5-carbonitrile. Acetoacetic and cyanoacetic esters under analogous conditions form anilides of 4-hydroxy-2-oxo-1, 2-dihydroquinoline-3-carboxylic acid while diethyl malonate gives N, N′-di-2-carboxyanilides of malonic acid.
Related Articles:
Ethyl esters of malonanilic acids. Synthesis and pyrolysis
[Ukrainets, Igor V.; Bezugly, Peter A.; Treskach, Vladimir I.; Taran, Svetlana G.; Gorokhova, Olga V. Tetrahedron, 1994 , vol. 50, # 34 p. 10331 - 10338]
Ethyl esters of malonanilic acids. Synthesis and pyrolysis
[Ukrainets, Igor V.; Bezugly, Peter A.; Treskach, Vladimir I.; Taran, Svetlana G.; Gorokhova, Olga V. Tetrahedron, 1994 , vol. 50, # 34 p. 10331 - 10338]