Bicyclic guanidino ketones

RA Houghten, RA Simpson, RN Hanson…

Index: Houghten,R.A. et al. Journal of Organic Chemistry, 1979 , vol. 44, p. 4536 - 4543

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Citation Number: 15

Abstract

Syntheses of bicyclic [3.3. 1] guanidino ketones are described by methods that permit the preparation of compounds substituted at the endo-and exocyclic nitrogen as well as at C-4. The primary synthetic method involved the; synthesis of substituted and protected 3- aminopiperidones and their subsequent cyclization with S, S-dimethyl N-@-toluenesulfony1) dithiocarbonimidate to the substituted and protected bicyclic guanidino ketones. The ...