Synthesis

Synthesis and study of 1-aryl-1H-4, 5-dihydroimidazoles

I Perillo, MC Caterina, J Lopez, A Salerno

Index: Perillo, Isabel; Caterina, M. Cristina; Lopez, Julieta; Salerno, Alejandra Synthesis, 2004 , # 6 p. 851 - 856

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Citation Number: 17

Abstract

Abstract An easy synthesis of 1-aryl-1H-4, 5-dihydroimidazoles 1 by cyclocondensation of N- aryl-N′-formylethylenediamines 2 is described. Such precursors were synthesized by selective formylation of N-arylethylenediamines 3 with p-nitrophenyl formate. Cyclizations were performed using trimethylsilyl polyphosphate. Chemical properties of compounds 1, typical of amidine system, were studied. Reaction of 1 with methyl iodide leads to the ...