A cannabinoid derived prototypical analgesic

LS Melvin, MR Johnson, CA Harbert…

Index: Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71

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Citation Number: 94

Abstract

Figure 1. Allinger's MMI calculation for 1 in 5'increments of rotation about the aryl-cyclohexyl ring bond. The 240 Newman projection overlaps the calculated least-energy conformation of HHC. and alcohol functionalities. Examination of Dreiding models of 1 relative to the conformationally rigid HHC molecule, however, revealed that structure 1 could readily adopt the orientation of the phenol and alcohol existing in HHC. Furthermore, a more detailed ...