Mammalian metabolism of phencyclidine

JK Baker, JG Wohlford, BJ Bradbury…

Index: Baker; Wohlford; Bradbury; Wirth Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 666 - 669

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Citation Number: 37

Abstract

In dogs, the major metabolite of phencyclidine was found to be 5-[N-(1'-phenylcyclohexyl) amino] pentanoic acid (1). The y-aminobutyric acid like metabolite was also pharmacologically evaluated to determine if the purported GABA-ergic mediated effects of phencyclidine on locomotor activity might be attributed to the metabolite. Preliminary pharmacological evaluation of 1 and ita methyl ester indicates that the metabolite has little ...