Tetrahedron: Asymmetry

Production of ring-substituted D-phenylglycines by microbial or enzymatic hydrolysis/deracemisation of the corresponding DL-hydantoins

MJ Garcia, R Azerad

Index: Garcia, Maria J.; Azerad, Robert Tetrahedron Asymmetry, 1997 , vol. 8, # 1 p. 85 - 92

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Citation Number: 46

Abstract

A series of 17 ring-mono and-disubstituted D-phenylglycine derivatives was prepared in high enantiomeric purity by enzymatic hydrolysis and deracemisation of the corresponding DL-hydantoins, using D-hydantoinase activities of microorganisms or purified enzymes, followed by diazotation of the resulting N-carbamyl D-amino acids. No significant L- hydantoinase activity was found to produce the corresponding L-enantiomers.