Novel thiocoumarins as inhibitors of TNF-α induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs) and microsomal lipid peroxidation

S Kumar, BK Singh, N Kalra, V Kumar, A Kumar…

Index: Kumar, Sarvesh; Singh, Brajendra K.; Kalra, Neerja; Kumar, Vineet; Kumar, Ajit; Prasad, Ashok K.; Raj, Hanumantharao G.; Parmar, Virinder S.; Ghosh, Balaram Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1605 - 1613

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Citation Number: 47

Abstract

Different coumarin/thiocoumarin derivatives, that is, 7-hydroxy-4-methylcoumarin, 7, 8- dihydroxy-4-methylcoumarin, 7-acetoxy-4-methylcoumarin, 7, 8-diacetoxy-4- methylcoumarin, 7-hydroxy-4-methylthiocoumarin, 7, 8-dihydroxy-4-methylthiocoumarin, 7- acetoxy-4-methylthiocoumarin and 7, 8-diacetoxy-4-methylthiocoumarin were synthesized and evaluated for their effects on TNF-α induced expression of intercellular adhesion ...