Studies on the Structure of Colchicine. 1 Syntheses in the Biphenyl Series

HR Frank, PE Fanta, DS Tarbell

Index: Frank; Fanta; Tarbell Journal of the American Chemical Society, 1948 , vol. 70, p. 2314,2317

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Citation Number: 14

Abstract

XVII XVIII In agreement with previous reports,'O it was found that the Rosenmund reduction of 3, 4, 5-trimethoxybenzoyl chloride gave variable yields; a byproduct, which in some runs was the main product, was shown to be the ester XVI, by hydrolysis to the expected compounds. This product has been observed by previous workers" but was not