Differential response of estrogen receptor subtypes to 1, 3-diarylindene and 2, 3-diarylindene ligands

…, S Paruthiyil, DC Leitman, TS Scanlan

Index: Clegg, Nicola J.; Paruthiyil, Sreenivasan; Leitman, Dale C.; Scanlan, Thomas S. Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5989 - 6003

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Citation Number: 81

Abstract

Estrogen receptors (ERs) control transcription of genes important for normal human development and reproduction. The signaling networks are complex, and there is a need for a molecular level understanding of the roles of receptor subtypes ERα and ERβ in normal physiology and as therapeutic targets. We synthesized two series of ER ligands, based on a common indene scaffold, in an attempt to develop compounds that can selectively ...