Naphthazarin derivatives (IV): synthesis, inhibition of DNA topoisomerase I and cytotoxicity of 2-or 6-acyl-5, 8-dimethoxy-1, 4-naphthoquinones
…, Y Kim, XG Zheng, YJ You, H Cho, JH Chung…
Index: Song, Gyu-Yong; Kim, Yong; Zheng, Xiang-Guo; You, Young-Jae; Cho, Hoon; Chung, Jin-Ho; Sok, Dai-Eun; Ahn, Byung-Zun European Journal of Medicinal Chemistry, 2000 , vol. 35, # 3 p. 291 - 298
Full Text: HTML
Citation Number: 40
Abstract
Some 2-or 6-acyl-5, 8-dimethoxy-1, 4-naphthoquinone (DMNQ) derivatives were synthesized and evaluated for inhibition of DNA topoisomerase I and cytotoxicity against L1210 cells. Compared with 2-acyl-DMNQ derivatives, 6-acyl-DMNQ compounds, bearing a higher electrophilic quinone moiety, showed a higher potency in the inhibition of DNA topoisomerase I and the cytotoxicity, implying the possible participation of electrophilic ...
Related Articles:
Synthesis of the monomeric unit of γ-actinorhodin
[Brimble, Margaret A.; Duncalf, Letecia J.; Phythian, Sara J. Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 9 p. 1399 - 1403]
Synthesis of the monomeric unit of γ-actinorhodin
[Brimble, Margaret A.; Duncalf, Letecia J.; Phythian, Sara J. Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 9 p. 1399 - 1403]
Synthesis of the monomeric unit of γ-actinorhodin
[Brimble, Margaret A.; Duncalf, Letecia J.; Phythian, Sara J. Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 9 p. 1399 - 1403]
Synthesis of the monomeric unit of γ-actinorhodin
[Brimble, Margaret A.; Duncalf, Letecia J.; Phythian, Sara J. Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 9 p. 1399 - 1403]