A novel synthesis of the. ALPHA.-hydroxyketone moiety of anthracyclinones by the use of 2-trimethylsilylethynylcerium (III) reagents.
M Suzuki, Y Kimura, S Terashima
Index: Suzuki, Michiyo; Kimura, Yoshikazu; Terashima, Shiro Chemistry Letters, 1984 , p. 1543 - 1546
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Citation Number: 28
Abstract
2-Trimethylsilylethynylcerium (III) reagents were found to efficiently react with 1, 2, 3, 4- tetrahydronaphthalene-2-one derivatives, giving the corresponding adducts in high yields. Hydration of the adducts readily afforded the α-hydroxy methyl ketones which are versatile synthetic intermediates of natural and unnatural anthracyclinones.
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