Histamine analogues. 33rd communication: 2-phenylhistamines with high histamine H 1-agonistic activity

V Zingel, S Elz, W Schunack

Index: Zingel, V.; Elz, S.; Schunack, W. European Journal of Medicinal Chemistry, 1990 , vol. 25, # 8 p. 673 - 680

Full Text: HTML

Citation Number: 42

Abstract

Abstract 2-Phenylhistamines with various substituents at the phenyl ring were synthesized and the influence of substitution in ortho, meta or para position on histamine H 1-agonistic activity was investigated. Compounds with high activity occurred in the meta phenyl series. Increased activity in the guinea-pig ileum assay was achieved by monosubstitution with halogen on the phenyl ring. 2-[2-(3-Fluorophenyl)-4-imidazolyl] ethanamine (12) is the ...