Rose Bengal analogs and vesicular glutamate transporters (VGLUTs)

N Pietrancosta, A Kessler, FC Favre-Besse…

Index: Pietrancosta, Nicolas; Kessler, Albane; Favre-Besse, Franck-Cyril; Triballeau, Nicolas; Quentin, Thomas; Giros, Bruno; Mestikawy, Salah El; Acher, Francine C. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 18 p. 6922 - 6933

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Citation Number: 18

Abstract

Vesicular glutamate transporters (VGLUTs) allow the loading of presynaptic glutamate vesicles and thus play a critical role in glutamatergic synaptic transmission. Rose Bengal (RB) is the most potent known VGLUT inhibitor (Ki 25nM); therefore we designed, ...