Synthesis and Conformational Properties of N, N-Dialkyl-6, 7-dihydro-5H-dibenzo [b, g][1, 5] thiazocinium Salts

LE Brieaddy, BS Hurlbert, NB Mehta

Index: Brieaddy, Lawrence E.; Hurlbert, B. Stuart; Mehta, Nariman B. Journal of Organic Chemistry, 1981 , vol. 46, # 8 p. 1630 - 1634

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Citation Number: 18

Abstract

cussed herein. The procedure of Gialdi et al. 6 was modified slightly to give 4 in nearly quantitative yields. The yield of the ester acid 6, despite varied attempts, never exceeded the stastically expected 50%. The preparation of the amido esters 7 and their reduction to the amino alcohols 8 proceeded without difficulty. Ring closure to the thiazocinium tosylates was achieved at room temperature within 3 h. Even at 0 “C, the reaction was complete within a ...