Trypanosoma cruzi: Activities of lapachol and α-and β-lapachone derivatives against epimastigote and trypomastigote forms

…, M Orellana, U Kemmerling, J Ferreira, JD Maya…

Index: Salas, Cristian; Tapia, Ricardo A.; Ciudad, Karina; Armstrong, Veronica; Orellana, Myriam; Kemmerling, Ulrike; Ferreira, Jorge; Maya, Juan Diego; Morello, Antonio Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 2 p. 668 - 674

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Citation Number: 74

Abstract

Derivatives of natural quinones with biological activities, such as lapachol, α-and β- lapachones, have been synthesized and their trypanocidal activity evaluated in vitro in Trypanosoma cruzi cells. All tested compounds inhibited epimastigote growth and trypomastigote viability. Several compounds showed similar or higher activity as compared with current trypanocidal drugs, nifurtimox and benznidazole. The results presented here ...