Tetrahedron Letters

The facile dealkylation of phosphonic acid dialkyl esters by bromotrimethylsilane

CE McKenna, MT Higa, NH Cheung, MC McKenna

Index: McKenna,C.E. et al. Tetrahedron Letters, 1977 , # 2 p. 155 - 158

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Citation Number: 353

Abstract

NC?. 2 157 tetrakis (trimethylsily1) esters under exceedingly mild conditions, typically 1-2 hr at 25". Specific examples comparing alkyl phosphonate silylations with (4a) and (4b) are presented in Table I. In a representative experiment, l-2 mnol of the neat phosphonate alkyl ester in an N2-filled, thermostatted nmr tube equipped with a septum stopper was treated with the indicated amount of (4b), injected with the aid of a plastic syringe. After mixing, the ...