Tetrahedron letters

Stereoselective CrCl 2-mediated condensation of aldehydes with functionalized 1, 1, 1-trichlorides: synthesis of trisubstituted (Z)-chloroolefins

…, A Bandyopadhyay, DK Barma, DS Shin, A Kundu…

Index: Falck; Bandyopadhyay, Anish; Barma; Shin, Dong-Soo; Kundu, Abhijit; Krishna Kishore Tetrahedron Letters, 2004 , vol. 45, # 15 p. 3039 - 3042

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Citation Number: 17

Abstract

The CrCl2-mediated condensation of aldehydes with a variety of functionalized 1, 1, 1- trichlorides affords trisubstituted chloroolefins in excellent yields and generally high Z- stereoselectivity. The intermediate dichlorohydrin adducts can be isolated in good yields under conditions of limited reagent and reduced temperature.