Tetrahedron

Steric tuning of C 2-symmetric chiral N-heterocyclic carbene in gold-catalyzed asymmetric cyclization of 1, 6-enynes

K Yamada, Y Matsumoto, KB Selim, Y Yamamoto…

Index: Yamada, Ken-Ichi; Matsumoto, Yasumasa; Selim, Khalid B.; Yamamoto, Yasutomo; Tomioka, Kiyoshi Tetrahedron, 2012 , vol. 68, # 22 p. 4159 - 4165

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Citation Number: 16

Abstract

Steric tuning of C2-symmetric chiral N-heterocyclic carbene (NHC) was performed in Au (I)- catalyzed asymmetric cyclization of 1, 6-enyne. Higher enantioselectivity was realized when chiral NHC–AuCl/AgSbF6 catalysts whose N-substituent on the NHC overlays the Au–Cl bond was utilized.