Subtype-selective N-methyl-D-aspartate receptor antagonists: benzimidazalone and hydantoin as phenol replacements

…, LD Wise, ER Whittemore, RM Woodward

Index: Schelkun; Yuen; Serpa; Meltzer; Wise; Whittemore; Woodward Journal of Medicinal Chemistry, 2000 , vol. 43, # 9 p. 1892 - 1897

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Citation Number: 39

Abstract

Previous work in our laboratories investigating compounds with structural similarity to ifenprodil (5) and 6 (CP101, 606) resulted in compound 7 as a potent and selective antagonist of the NR1/2B subtype of the NMDA receptors. Replacement of the phenol group of 7 with a benzimidazalone group tethered by a three-carbon chain to 4-benzylpiperidine resulted in a slightly less active, but selective, compound. Lengthening the carbon tether ...