N-Arylated pyrrolidin-2-ones and morpholin-3-ones as potassium channel openers
PH Liang, LW Hsin, CY Cheng
Index: Liang, Pi-Hui; Hsin, Ling-Wei; Cheng, Chen-Yu Bioorganic and medicinal chemistry, 2002 , vol. 10, # 10 p. 3267 - 3276
Full Text: HTML
Citation Number: 30
Abstract
Based on the most stable conformation of ZD6169, a series of N-arylated derivatives of oxazolidindione (2), morpholin-3-one (3–5), piperidin-2-one (6), and pyrrolidin-2-one (7–13) was synthesized and evaluated for potassium channel opening activity. In the in-vitro assays, N-(4-benzoylphenyl)-piperidin-2-one (6) and N-(4-benzoylphenyl)-3, 3-dimethyl- pyrrolidin-2-one (9) demonstrated potent and selective relaxant activity at the bladder ...
Related Articles:
[Reilly, Maureen K.; Rychnovsky, Scott D. Organic Letters, 2010 , vol. 12, # 21 p. 4892 - 4895]
Pig-liver-esterase-catalyzed hydrolyses of racemic. alpha.-substituted. alpha.-hydroxy esters
[Moorlag, Henk; Kellogg, Richard M.; Kloosterman, Marcel; Kaptein, Bernard; Kamphuis, Johan; Schoemaker, Hans E. Journal of Organic Chemistry, 1990 , vol. 55, # 23 p. 5878 - 5881]
[Yasuda, Makoto; Sugawa, Yoshihiro; Yamamoto, Akihiro; Shibata, Ikuya; Baba, Akio Tetrahedron Letters, 1996 , vol. 37, # 33 p. 5951 - 5954]
Solvent-mediated allylation of carbonyl compounds with allylic stannanes
[Cokley, Teresa M.; Harvey, Peta J.; Marshall, Raymond L.; McCluskey, Adam; Young, David J. Journal of Organic Chemistry, 1997 , vol. 62, # 7 p. 1961 - 1964]