Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate

J Regan, S Breitfelder, P Cirillo, T Gilmore…

Index: Journal of Medicinal Chemistry, , vol. 45, # 14 p. 2994 - 3008

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Citation Number: 317

Abstract

... Departments of Medicinal Chemistry, Biology, and Pharmacology, Boehringer Ingelheim Pharmaceuticals, Research and ... applications on imidazole-based compounds, 25-27 several journal papers have ... Following the chemistry described in Scheme 1, pyrazole formation and ...

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